The GWAS hoax....or was it a hoax? Is it a hoax?

A long time ago, in 2000, in Nature Genetics , Joe Terwilliger and I critiqued the idea then being pushed by the powers-that-be, that the g...

complex traitscomplexitygene mappinggeneticsGWASomnigenic

Causal complexity in life

E volution is the process that generates the relationships between genomes and traits in organisms.  Although we have written extensively an...

adaptationaltitudecomplex causalitycomplexityevolutionevolution by phenotypephenogenetic drift

Genomic causation....or not

By Ken Weiss and Anne Buchanan T he Big Story in the latest Nature  ("A radical revision of human genetics: Why many ‘deadly’ gene mut...

Big Datacausationcomplex causationcomplexitygeneticsGWAS

Another look at 'complexity'

A fascinating and clear description of one contemporary problem of sciences involved in 'complexity' can be found in an excellent d...

causationcomplexityprediction

Statistical Reform.....or Safe-harbor Treadmill Science?

W e have recently commented on the flap in statistics circles about the misleading use of significance test results ( p -values) rather than...

causationcomplexitygeneticssciencestatistics

We're all fundamentalists now

I f you're a foodie at all, you've heard of Yotam Ottolenghi , chef, restauranteur, and food writer.  Perhaps you've used some o...

complexityfundamentalismgenetics

Life in 'trans'-it: Why genomic causation is often so elusive

W e are in a time when genes are in the daily news, with reports of how this gene or that gene is related to disease, evolution, race, ances...

causal complexitycis-complexitycooperationgene functiontrans-