The continuing trials and tribulations of PACE

I honestly hadn't intended talking about the PACE trial  - " pacing, graded activity, and cognitive behaviour therapy: a randomised...

behaviourCBTChronic fatigue syndrome (CFS)graded exercise therapy (GET)myalgic encephalomyelitis (ME)PACE trialsciencescientific method

When scientific theory constrains

I t's good from time to time to reflect on how we know what we think we know.  And to remember that, as it has been in any time in histo...

assumptionssciencescientific methodtheory

The Blind Men and the Elephant -- a post-modern parable

I t's an ancient parable; a group of blind men are lead to an elephant and asked to describe what they feel.  One feels a tusk, another ...

inductionscientific method

How do we know what we think we know?

T wo stories collided yesterday to make me wonder, yet again, how we know what we think we know.  The first was from the latest BBC Radio 4 ...

complexityevolutiongenetic determinisminductionscientific method

It's not just about psych studies; it's about core aspects of inference.

A   paper just published in Science by the "Open Science Collaboration" reports the results of a multi-year multi-institution ef...

human geneticspsychologyreplicabilityscientific method

The best books... are those that tell you what you know already

The title for this post comes from a quote in George Orwell's  Nineteen Eighty-Four . I'm using it to plug the fact that as from tod...

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Parent power: autism and carnitine

For many years, science and the conducting of science, was seen as quite an exclusive club. Men and women in white laboratory coats holding ...

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Adaptive..yawn..trial design

My name is Paul and I am interested in clinical trial design. OK, it is hardly the chat-up line of the year. I also don't think I am goi...

adaptive trial designclincial trialevidence-based medicineinterventionscientific method

Measuring evidence in autism

A few weeks back I had the pleasure of an email conversation with Dr Gary Mesibov on the topic of one of his recent papers titled: 'Evid...

autismevidence-based medicineinterventionnicescientific method

On the Hippocratic Oath

I have more than a passing interest in all things Greek - particularly the language, which I have been learning for the past 10 years or so,...

evidence-based medicinehippocratic oathscientific method

Autism and n=1

The post carries a warning that it is best to read whilst sitting comfortably with a glass of wine and an open mind. Sitting comfortably? Fe...

autismevidence-based medicinescientific method