The GWAS hoax....or was it a hoax? Is it a hoax?

A long time ago, in 2000, in Nature Genetics , Joe Terwilliger and I critiqued the idea then being pushed by the powers-that-be, that the g...

complex traitscomplexitygene mappinggeneticsGWASomnigenic

Pleiotropy, genomic background, and complexity

A recent paper in Nature Reviews: Genetics , "Pleiotropy in complex traits: challenges and strategies" (Solovieff et al.) raises s...

complex traitspleiotropy

Dogs, crows and garbage: phenogenetic drift

Scavenger hunts Monday's the day trash gets picked up in our neighborhood. When I was out running early this Monday morning, I passed a ...

complex traitsphenogenetic driftvariation

The mind boggles

Schizophrenia is one of those important human traits that has eluded understanding despite heavy research investment. It is elusively varia...

association studiesbehavioral evolutionbipolarcomplex diseasecomplex trait geneticscomplex traitsgene mappingGWASmanic-depressiveschizophrenia

A gene 'for' depression that isn't

A new study published in the Journal of the American Medical Association today, and receiving a lot of media attention (e.g., here and here...

behavioral geneticscomplex traitsdepressionGWASJAMAMerikangasmeta analysisRisch