Cystic fibrosis, genetic variation and gene function

We wrote last week about the difficulty in assessing gene function, including determining whether a given genetic variant is in fact respons...

allelic variationcystic fibrosisDNA sequencinggene function

When the crystal ball is cloudy: calling sequence data correctly

Here's a monkey wrench of a paper  (O'Rawe et al.), just published in Genome Medicine .  We're all being sold on the idea that k...

DNA sequencingepistemology

Gutting it out

Only a small fraction of bacteria can be grown in laboratories; apparently nobody understands what they need in their environment well enoug...

antiobiotic resistancebacteriaDNA sequencingE. colievolutionary ecologymetagenomicsmicrobiomeplasmids