Life in 'trans'-it: Why genomic causation is often so elusive

W e are in a time when genes are in the daily news, with reports of how this gene or that gene is related to disease, evolution, race, ances...

causal complexitycis-complexitycooperationgene functiontrans-

The taste of heat

We've posted a few times recently about the ease of identifying genes, but the inherent difficulty of determining their function.  E.g.,...

Drosophilagene functionscientific humilitytaste receptorsthermosensing

Cystic fibrosis, genetic variation and gene function

We wrote last week about the difficulty in assessing gene function, including determining whether a given genetic variant is in fact respons...

allelic variationcystic fibrosisDNA sequencinggene function

Genes 'for' XLID -- the replication/falsifiability fallacy

How do we know when a particular gene variant actually causes a trait?   A recent paper in the American Journal of Human Genetics (XLID-Cau...

causationgene functionGWASreplication